Presentation Type
Event
Description
Cancer remains the second leading cause of death in the United States, underscoring the urgent need for more effective treatment options. Nanotechnology offers innovative solutions through combination nanomedicines that can integrate multiple therapeutic mechanisms into a single platform. In this study, we developed aqueous nanoparticles (NPs) composed of a combined chemotherapeutic agent and photothermal therapy drug,[DOX][IR820], using a simple reprecipitation method. By adjusting different parameters, we tuned NP size and evaluated how this influenced their photophysical behavior, such as absorbance and fluorescence emission, and photothermal therapeutic activity such as light-to-heat conversion efficiency. These properties were analyzed to identify the optimal nanoparticle formulation to attain enhanced phototherapeutic performance of the drug.
Recommended Citation
Nadeem, Eshaal; Abbas, Fatima; and Siraj, Noureen, "Photophysical Properties of Tunable DOX-IR820 Chemo-PTT Combination Nanomedicine" (2026). Research and Creative Works Expo. 2.
https://research.ualr.edu/expo/2026/presentations/2
Included in
Photophysical Properties of Tunable DOX-IR820 Chemo-PTT Combination Nanomedicine
Cancer remains the second leading cause of death in the United States, underscoring the urgent need for more effective treatment options. Nanotechnology offers innovative solutions through combination nanomedicines that can integrate multiple therapeutic mechanisms into a single platform. In this study, we developed aqueous nanoparticles (NPs) composed of a combined chemotherapeutic agent and photothermal therapy drug,[DOX][IR820], using a simple reprecipitation method. By adjusting different parameters, we tuned NP size and evaluated how this influenced their photophysical behavior, such as absorbance and fluorescence emission, and photothermal therapeutic activity such as light-to-heat conversion efficiency. These properties were analyzed to identify the optimal nanoparticle formulation to attain enhanced phototherapeutic performance of the drug.
