Date of Award

9-4-2015

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Bioinformatics

First Advisor

Daniel Berleant

Abstract

The goal of the Translating Time: Eye Development research project is to increase understanding of unknown times of prenatal eye development events in mammals, especially in humans, based on the limited set of known timing of such events. The primary mammalian models included nine eutherian mammals: Felis domestica (cat), Mustela putorius furo (ferret), Mesocricetus auratus (hamster), Macaca mulatta (monkey), Homo sapiens (humans), Mus musculus (mouse), Oryctolagus cuniculus (rabbit), Rattus norvegicus (rat), and Acomys cahirinus (spiny mouse). The main subgoals of this research were to: mine the literature to identify a data set of eye development events for the selected placental mammals, determine the Gene Ontology annotations associated with the data set of the mined eye development events, predict unknown events in eye development for the selected organisms, and develop an internet-based resource for sharing the data and the methods that were developed for predicting eye development events. Since the Danio rerio (zebrafish) is considered a model organism for research in eye development, it was also investigated to determine whether or not it fits the model.

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