Date of Award
5-7-2020
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Systems Engineering
First Advisor
Alexandru Biris
Abstract
Tissue engineering is a promising alternative treatment for damaged tissues. In bone regeneration, bone graft replacements can be made from different biomaterials (basically ceramic and polymer) and used for different treatment purposes. In the first section of this dissertation, the Compression test results showed that its modulus of elasticity depends on its porosity. Also, we developed a testing method to measure the swelling force of the material during expansion due to liquid absorption. The maximum swelling force was found to be proportional to the material modulus. In the second part, we successfully design, fabricate and characterize a novel expandable bone scaffold that can self-expand inside a bone defect to adapt to its unique shape and fill the defect. This scaffold can expand about 3.62 times its original volume, biological study showed that it is non-cytotoxic, biocompatible and promotes cells in growth matrix, in vivo study showed early collagen formation, and has strong healing characteristics. The material was observed to handle well in surgical applications.
Recommended Citation
mhanawee, Anwer, "Biomaterials for Bone Regeneration: Tunable Structural and Mechanical Characteristics" (2020). Theses and Dissertations. 933.
https://research.ualr.edu/etd/933
