Date of Award
2007
Document Type
Thesis
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Ali U. Shaikh, Ph.D.
Abstract
Sulfonamide drugs discovered in the 1930's were the first effective chemotherapeutic agents to be employed for the prevention and cure of bacterial infections in humans. Bacterial resistance to these drugs over the years has led to the development of new variety of sulfonamide derivatives. Recently Chohan et al. synthesized a series of coumarin derived sulfonamides and their chemical structures have been established. In this report, we present some microbiological studies to establish the antibacterial characters of these compounds. In order to establish their chemical structure-biological activity relationship, electrochemical and spectroscopic studies have been conducted. Antibacterial studies conducted on these compounds revealed a few active, a few partially active and some inactive compounds. Correlation was not observed between the structure and bacterial efficacy of these compounds. UV-Visible spectroscopy was used to determine pKa of these compounds, but was not successful due to their insolubility. Absorption bands of these compounds followed a similar pattern and were characterized based on the structure. To understand the electrochemical behavior of these compounds cyclic voltammetric studies have been performed in both non-aqueous and aqueous media. Studies in aqueous media have shown no oxidation or deduction peaks, whereas in DMSO, the reduction peaks were observed ranging from -932 mV to -1697 mV, but no oxidation peaks appeared within the potential range.
Recommended Citation
Gosike, Harish, "Evaluation and Characterization of Some Biologically Active Coumarin Derived Sulfonamides" (2007). Theses and Dissertations. 80.
https://research.ualr.edu/etd/80
