Date of Award

8-9-2017

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Systems Engineering

First Advisor

Coşkun Bayrak

Abstract

Diabetes mellitus has been steadily increasing for the past three decades and has been one of the major causes of death. Diabetes may develop serious complications as well. Even though diabetes can be controlled without developing severe complications by steady checking of glucose level, the physical pain in pricking fingers and the emotional distress associated with using conventional invasive glucose meter make diabetics neglect self-monitoring of blood glucose. Hence, the improvement of non-invasive glucose measurement technology could give a huge effect on diabetes patient for not only improving health but also an economic benefit. However, no non-invasive glucose monitoring device assures the reliability of direct finger-pricking blood sensor technology up to now. Within this scope, this research investigates the feasibility of developing a handheld device which will reveal the non-invasive reading of a blood glucose level in most practical, efficient, and cost effective way comparable to conventional invasive glucose measurement. To reach the accuracy of conventional invasive glucose measurement, multivariate sensoring technology consists of the combination of different techniques within the same device for the detection and compensation of those perturbations which are responsible for the non-accuracy of the non-invasive sensor. For one-hand operation, the glucoase should be measured on a palm. In this context, breath analyzing and Raman spectroscopy are proposed for multivariate sensoring. In the thesis, Raman spectrocopy based non-invasive glucose measurement is studied because one-hand operation needs to measure the glucose on a palm holding a device simultaneously. The recent remarkable theories of Raman technique are reviewed, and the experiments in acquiring Raman spectra on a palm are conducted. After analyzing the study, the limitations of Raman spectroscopy technique for developing handheld non-invasive glucose monitoring are stated. Consequently, Raman spectroscopy based non-invasive glucose measurement has an advantage to predict the glucose level in bloodless method, but continuing work is also needed to overcome the limitation of Raman technique to develop the handheld non-invasive glucose monitor.

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