Date of Award

4-6-2026

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Applied Science

First Advisor

Alexandru Biris

Abstract

Injuries and damaged bones resulting from trauma or disease can lead to significant health complications that are challenging to address with current clinical methods for critical-sized defects. This challenge arises primarily from the intricate anatomy and physiology of bone tissue and the limitations of existing medical technology. This research introduces innovative techniques and types of biomaterials designed to bridge the knowledge gap in manufacturing bone scaffolds. The objective is to refine a novel approach to creating bone scaffolds and to assess their biomedical applications. Previous studies have indicated that these scaffolds can deliver medications or a combination of drugs to aid in healing bone infections. This dissertation outlines various techniques for fabricating bone scaffolds to aid in the delivery of such pharmacological interventions. The porosity of these scaffolds is a critical factor, as it affects the quantity of medication that can be loaded and released, making it vital to understand its implications for biomedical applications, and an additional aspect of this research will explore the combination of two different polymers used in bone scaffolds to evaluate how polymer type influences scaffold performance. Also, this dissertation outlines two research initiatives that are anticipated to be completed within approximately 60 weeks, following a well-structured project plan that details the essential activities required for successful execution. The findings from these studies aim to enhance the treatment and healing of bone diseases by enabling the production of effective scaffolds under optimal conditions.

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