Date of Award
11-15-2024
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Noureen Siraj
Abstract
This dissertation is focused on the development of novel class of ionic materials (IMs), and ionic nanomedicines (INMs) for cancer treatment. These IMs are composed of two therapeutics combined via electrostatic attraction. The impact of various counterions on the drug’s cytotoxic and photophysical properties are unveiled. Moreover, the mechanism of internalization, enhanced toxicity of these materials is investigated by determining their cellular uptake, subcellular localization, and cell death mechanism. Furthermore, the in vivo bioimaging capabilities of the drugs is investigated to validate their potential for clinical relevance. The second part of this dissertation is focused on the synthesis of biocompatible hydrogels for use as a drug delivery vehicle. These hydrogels exhibit unique properties including sol-gel transition temperature, swelling ratio, drug release profile and rheology results that are promising for drug delivery application.
Recommended Citation
Bashiru, Mujeebat, "Ionic Nanomedicines and Biocompatible Hydrogel: Synthesis, Characterization and Application in Cancer and Drug Delivery" (2024). Theses and Dissertations. 1229.
https://research.ualr.edu/etd/1229
