Date of Award

6-14-2024

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Mathematics and Statistics

First Advisor

Hassan Elsalloukh

Abstract

Perfluorooctane sulfonate (PFOS) are widely used for industrial and commercial purposes and have received increasing attention due to their adverse effects on health. This thesis investigates the relationship between PFOS exposure and blood glucose levels, considering potential confounding factors. Regression analysis was conducted on a dataset comprising demographic, lifestyle, and biomarker data from a diverse population sample. Sex exhibited a significant role, with females demonstrating an 11.77% increase in blood glucose levels in response to PFOS exposure compared to males, supported by a p-value of 1.04 × 109. Body mass index (BMI) also played a pivotal role, revealing a 2.17% increase in blood glucose levels for every unit rise in BMI, with a p-value of 1.69×10−9, emphasizing the impact of adiposity on PFOS-mediated metabolic effects. Race of individuals revealed differential impacts an 11.07% increase in blood glucose levels following PFOS exposure, supported by a p-value of 2.25×10−10, while Diet quality demonstrated nuanced effects with a 1.75% increase in blood glucose levels compared to the reference category, with a p-value of 7.61 × 10−9. Smoking habits suggested a potential interaction, with smokers experiencing a 1.46% increase in PFOS-mediated blood glucose levels. Lastly, Sedentary behavior emerged as a significant modifier, with individuals engaging in higher levels of sedentary activity manifesting a decrease in PFOS-mediated blood glucose levels, supported by a p-value of 0.000831. However, the practical implications of this association warrant further exploration.

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