Date of Award

12-5-2023

Document Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Applied Science

First Advisor

Noureen Siraj

Abstract

In this dissertation, the novel class of ionic materials is explored. Ionic materials are easily tuned and tailored to fit a wide variety of applications. The synthesis of ionic materials is extremely simple and prompt. Briefly, two ionic moieties are joined electrostatically through a double displacement resulting in a new compound without complicated synthesis. This process leads to a close proximity of the ions which allows for enhancement of the FRET mechanism between a fluorophore and chromophore. A potential application of a FRET active ionic material is explored as a photosensitizer using IR820 and Nile Blue A. The ionic material, [NBA][IR820], exhibits excellent photophysical properties and enhanced energy transfer mechanism. Another FRET -based ionic materials, consisting of carbazole imidazolium and fluorescein ([Cl]2[Fl]) was synthesized and characterized to apply as a bioimaging agent. [Cl]2[Fl] was converted into an ionic nanoparticle and utilized as a pH-probe and bioimaging agent in in vitro studies. Ionic nanoparticles are further investigated in antimicrobial applications. The ionic material consisting of the commercial antibiotic, Norfloxacin, and the photothermal agent, IR780, was synthesized to create a dual mechanism antibiotic. The ionic nanoparticle showed excellent cellular uptake and antibiotic activity as compared to the individual moieties.

Download

Included in

Chemistry Commons

Share

COinS